Checkpoint Inhibitors Side Effects

Since these drugs rev up your immune system they can cause a range of side effects including fatigue cough nausea loss of appetite rash and problems in your lungs kidneys intestines.

Checkpoint inhibitors side effects.

However immune checkpoint blockade can lead to the breaking of immune self tolerance thereby inducing a novel syndrome of autoimmune autoinflammatory side effects designated as immune related adverse events mainly including rash colitis hepatitis and endocrinopathies. Other immune checkpoint inhibitors are under clinical evaluation. Occasional any grade toxicities in 5 20 of patients include fatigue headache arthralgia rash pruritus pneumonitis diarrhoea and or colitis hepatitis and endocrinopathies table 1. On average symptoms appear around nine weeks after starting treatment and may include.

Mp inflammatory reactions involving the skin and the gastrointestinal tract are among the most common adverse events seen with checkpoint inhibitors. He says he figures these are just normal side effects of his medication. After about six months of therapy john tells you that over the past four weeks he has been experiencing increased fatigue weight gain insomnia and constipation. Common side effects associated with currently approved checkpoint immunotherapies may include but are not limited to.

Paying careful attention to potential symptoms is therefore crucial. Fatigue rash colitis infusion related reactions diarrhea asthenia arthralgias constipation decreased appetite cough dyspnea headache insomnia nausea pain including in the abdomen back and musculoskeletal system peripheral edema pneumonitis radiation pneumonitis pruritus pyrexia vomiting and weight loss. Besides headache dizziness and apathy ataxia tremor paralysis myoclonus cognitive impairment speech disorders and even seizures may occur. The most common side effects of checkpoint inhibitors are.

Checkpoint inhibitor associated neurological side effects are rare but potentially life threatening.